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This construct is referred to as a tet-controlled transactivator (tTA) and it regulates expression of a target nucleic acid sequence that is under transcriptional control of a tetracycline-responsive promoter element (TRE).

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It mirapex uk proportionably will be appreciated by those skilled in the art that various combinations of activator and inhibitor proteins can be used to regulate a single tetO-linked gene of interest in both a positive and negative manner or to regulate multiple tetO-linked genes of interest in a coordinated manner or in an independent manner using the teachings described herein! With respect to Candida onychomycosis, terbinafine has only limited and unpredictable in vitro activity [ 294, 295] and has not demonstrated consistently good activity in clinical trials [ 296]?
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